| Matchday 1 |
| 13.03.2010, Saturday |
| Lokomotiv | 3-1 | Neftchi | |
| Nasaf | 0-0 | Shurtan | |
| Qizilqum | 0-1 | Metallurg | |
| Dynamo | 1-1 | Khorezm | |
| Navbahor | 0-0 | Mashal | |
| 14.03.2010, Sunday |
| Bunyodkor | 2-1 | Pakhtakor | |
| Andijan | 3-2 | Olmaliq | |
| Matchday 2 |
| 18.03.2010, Thusday |
| Pakhtakor | 1-0 | Dynamo | |
| 19.03.2010, Friday |
| Metallurg | 0-1 | Bunyodkor | |
| Shurtan | 0-0 | Qizilqum | |
| 20.03.2010, Saturday |
| Neftchi | 3-0 | Olmaliq | |
| Mashal | 1-0 | Andijan | |
| Khorezm | 0-1 | Navbahor | |
| 28.03.2010, Sunday |
| Lokomotiv | 0-0 | Nasaf | |
| Matchday 3 |
| 02.04.2010, Friday |
| Nasaf | 2-0 | Neftchi | |
| 03.04.2010, Saturday |
| Qizilqum | 0-1 | Lokomotiv | |
| Bunyodkor | 1-1 | Shurtan | |
| Dynamo | 0-0 | Metallurg | |
| Andijan | 0-0 | Khorezm | |
| Olmaliq | 0-0 | Mashal | |
| 04.04.2010, Sunday |
| Navbahor | 0-1 | Pakhtakor | |
| Matchday 4 |
| 08.04.2010, Thusday |
| Pakhtakor | 0-0 | Andijan | |
| 09.04.2010, Friday |
| Khorezm | 1-1 | Olmaliq | |
| Lokomotiv | 0-4 | Bunyodkor | |
| 10.04.2010, Saturday |
| Neftchi | 3-0 | Mashal | |
| Metallurg | 0-2 | Navbahor | |
| Shurtan | 2-0 | Dynamo | |
| 12.04.2010, Monday |
| Nasaf | 1-0 | Qizilqum | |
| Matchday 5 |
| 17.04.2010, Saturday |
| Qizilqum | 2-1 | Neftchi | |
| Dynamo | 2-0 | Lokomotiv | |
| Andijan | 2-1 | Metallurg | |
| Mashal | 0-0 | Khorezm | |
| 18.04.2010, Sunday |
| Navbahor | 4-0 | Shurtan | |
| Olmaliq | 2-3 | Pakhtakor | |
| Matchday 6 |
| 22.04.2010, Thusday |
| Pakhtakor | 1-0 | Mashal | |
| 23.04.2010, Friday |
| Qizilqum | 1-1 | Bunyodkor | |
| 24.04.2010, Saturday |
| Neftchi | 1-0 | Khorezm | |
| Metallurg | 1-0 | Olmaliq | |
| Shurtan | 2-1 | Andijan | |
| Lokomotiv | 1-3 | Navbahor | |
| Matchday 7 |
| 01.05.2010, Saturday |
| Dynamo | 0-0 | Qizilqum | |
| Andijan | 2-0 | Lokomotiv | |
| Olmaliq | 1-0 | Shurtan | |
| Mashal | 1-1 | Metallurg | |
| 02.05.2010, Sunday |
| Bunyodkor | 1-0 | Neftchi | |
| Navbahor | 1-1 | Nasaf | |
| Khorezm | 0-1 | Pakhtakor | |
| Matchday 8 |
| 06.05.2010, Thusday |
| Neftchi | 3-3 | Pakhtakor | |
| Nasaf | 3-1 | Andijan | |
| Bunyodkor | 2-1 | Dynamo | |
| 08.05.2010, Saturday |
| Metallurg | 3-1 | Khorezm | |
| Shurtan | 1-0 | Mashal | |
| Lokomotiv | 0-0 | Olmaliq | |
| Qizilqum | 1-0 | Navbahor | |
| Matchday 9 |
| 15.05.2010, Saturday |
| Dynamo | 3-1 | Neftchi | |
| Qizilqum | 2-1 | Andijan | |
| Mashal | 1-0 | Lokomotiv | |
| Khorezm | 0-2 | Shurtan | |
| 16.05.2010, Sunday |
| Navbahor | 1-2 | Bunyodkor | |
| Olmaliq | 0-0 | Nasaf | |
| 17.05.2010, Monday |
| Pakhtakor | 2-0 | Metallurg | |
| Matchday 10 |
| 24.05.2010, Monday |
| Lokomotiv | 2-1 | Khorezm | |
| 22.05.2010, Saturday |
| Neftchi | 3-3 | Metallurg | |
| 21.05.2010, Friday |
| Shurtan | 1-2 | Pakhtakor | |
| Nasaf | 3-1 | Mashal | |
| 22.05.2010, Saturday |
| Qizilqum | 1-0 | Olmaliq | |
| Bunyodkor | 1-0 | Andijan | |
| Dynamo | 1-0 | Navbahor | |
| Matchday 11 |
| 27.05.2010, Thusday |
| Dynamo | 2-0 | Andijan | |
| 28.05.2010, Friday |
| Khorezm | 1-2 | Nasaf | |
| 29.05.2010, Saturday |
| Olmaliq | 1-3 | Bunyodkor | |
| Navbahor | 1-1 | Neftchi | |
| Mashal | 0-2 | Qizilqum | |
| Pakhtakor | 4-2 | Lokomotiv | |
| Metallurg | 2-1 | Shurtan | |
| Matchday 12 |
| 04.06.2010, Friday |
| Neftchi | 0-2 | Shurtan | |
| Lokomotiv | 1-0 | Metallurg | |
| Qizilqum | 1-0 | Khorezm | |
| 05.06.2010, Saturday |
| Nasaf | 1-1 | Pakhtakor | |
| Bunyodkor | 3-0 | Mashal | |
| Dynamo | 4-2 | Olmaliq | |
| Navbahor | 2-0 | Andijan | |
| Matchday 13 |
| 27.07.2010, Tuesday |
| Andijan | 1-0 | Neftchi | |
| 13.06.2010, Sunday |
| Mashal | 2-1 | Dynamo | |
| Pakhtakor | 0-0 | Qizilqum | |
| 14.06.2010, Monday |
| Metallurg | 0-0 | Nasaf | |
| Olmaliq | 2-1 | Navbahor | |
| Khorezm | 0-1 | Bunyodkor | |
| Shurtan | 3-2 | Lokomotiv | |
| Matchday 6 |
| 01.06.2010, Tuesday |
| Nasaf | 2-1 | Dynamo | |
| Matchday 27 |
| 27.07.2010, Tuesday |
| Andijan | 1-0 | Neftchi | |
| 28.07.2010, Wednesday |
| Bunyodkor | 0-0 | Nasaf | |
| Matchday 14 |
| 01.08.2010, Sunday |
| Neftchi | 1-1 | Andijan | |
| Navbahor | 0-1 | Olmaliq | |
| Dynamo | 1-1 | Mashal | |
| Bunyodkor | 4-1 | Khorezm | |
| 31.07.2010, Saturday |
| Qizilqum | 0-1 | Pakhtakor | |
| 01.08.2010, Sunday |
| Nasaf | 2-0 | Metallurg | |
| Lokomotiv | 0-1 | Shurtan | |
| Matchday 15 |
| 05.08.2010, Thusday |
| Shurtan | 2-0 | Neftchi | |
| Metallurg | 1-0 | Lokomotiv | |
| Pakhtakor | 2-0 | Nasaf | |
| Khorezm | 3-1 | Qizilqum | |
| Mashal | 0-2 | Bunyodkor | |
| Olmaliq | 3-1 | Dynamo | |
| Andijan | 5-1 | Navbahor | |
| Matchday 16 |
| 14.08.2010, Saturday |
| Neftchi | 0-0 | Navbahor | |
| Andijan | 0-0 | Dynamo | |
| Bunyodkor | 0-0 | Olmaliq | |
| Qizilqum | 0-0 | Mashal | |
| Nasaf | 0-0 | Khorezm | |
| Shurtan | 0-0 | Metallurg | |
| 15.08.2010, Sunday |
| Lokomotiv | 0-0 | Pakhtakor | |
| Matchday 17 |
| 21.08.2010, Saturday |
| Metallurg | 0-0 | Neftchi | |
| Khorezm | 0-0 | Lokomotiv | |
| Mashal | 0-0 | Nasaf | |
| Olmaliq | 0-0 | Qizilqum | |
| Navbahor | 0-0 | Dynamo | |
| 22.08.2010, Sunday |
| Pakhtakor | 0-0 | Shurtan | |
| Andijan | 0-0 | Bunyodkor | |
| Matchday 18 |
| 26.08.2010, Thusday |
| Neftchi | 0-0 | Dynamo | |
| Bunyodkor | 0-0 | Navbahor | |
| Qizilqum | 0-0 | Andijan | |
| Matchday 19 |
| 11.09.2010, Saturday |
| Pakhtakor | 0-0 | Neftchi | |
| Matchday 18 |
| 26.08.2010, Thusday |
| Lokomotiv | 0-0 | Mashal | |
| 27.08.2010, Friday |
| Shurtan | 0-0 | Khorezm | |
| 26.08.2010, Thusday |
| Metallurg | 0-0 | Pakhtakor | |
| Nasaf | 0-0 | Olmaliq | |
| Matchday 19 |
| 11.09.2010, Saturday |
| Khorezm | 0-0 | Metallurg | |
| Mashal | 0-0 | Shurtan | |
| Olmaliq | 0-0 | Lokomotiv | |
| 12.09.2010, Sunday |
| Andijan | 0-0 | Nasaf | |
| 11.09.2010, Saturday |
| Navbahor | 0-0 | Qizilqum | |
| 12.09.2010, Sunday |
| Dynamo | 0-0 | Bunyodkor | |
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